20 miliardi di euro l’anno: i costi per il cancro in Italia – Prevenzione attiva, la vera arma vincente
Mitochondrial toxicity is often associated with the effect of drugs, environmental toxins, and metabolic diseases that interfere with the normal function of the mitochondria. While there is no single universally recognized index or standard marker for mitochondrial toxicity, several indicators are commonly used in research to identify mitochondrial damage and dysfunction. To date, the most suitable technology, for the industrialization of a blood test-based service to analyze mitochondrial toxicity levels, is the Seahorse XF Analyzer (Agilent Technologies), which measures the oxygen consumption rate (OCR) and the extracellular acidification rate (ECAR) in live cells in a multi-well plate format, providing an assessment of cellular respiration and glycolysis, respectively. However, this test is only used to analyze the increase in toxicity after the administration of a drug, or the toxicity on cells already compromised by the disease.
